![]() It is capable of carrying “doomsday” Poseidon nuclear torpedo drones, which, according to Russia, could trigger 1,600-foot nuclear tsunamis that would inundate coastal cities from hundreds of miles away and render them uninhabitable for decades. ![]() Measuring more than 600 feet in length, the Belgorod is the largest submarine in the world. Meanwhile, NATO warned its member states, including the US, that Russia’s Belgorod nuclear submarine has left its base in the Arctic Circle, the Italian newspaper La Repubblica reported. Rybar The train is allegedly associated with the 12th Main Directorate of the Russian Ministry of Defense, which is responsible for maintaining the country’s nuclear arsenal. This screenshot from a video shows a freight train hauling upgraded armored personnel carriers moving through central Russia towards the front lines. The APCs reportedly belong to the secretive 12th Main Directorate of the Russian Ministry of Defense, which is responsible for maintaining the country’s nuclear arsenal. The pro-Russian Telegram channel Rybar shared on Sunday a video showing a freight train hauling upgraded armored personnel carriers (APCs) and other sophisticated military equipment through central Russia, the Daily Mail reported. These latest maneuvers could signal an increasingly desperate Vladimir Putin’s willingness to escalate the war following a series of embarrassing defeats on the battlefield, including the loss of a key city in Donetsk and the most recent setbacks in the Kherson region. Why the US military almost blew the moon up with a nuclear bombĪ military train that belongs to the forces responsible for Russia’s nuclear arsenal has been spotted moving toward the front lines in Ukraine, while Moscow was said to have deployed the world’s biggest submarine - capable of carrying “apocalypse” drones. ‘Terrorist’ Putin is turning plant into improvised nuke, ex-military official warns Wagner boss ‘afraid’ Russia may use nuclear weapons on its own territory Legendary blind mystic makes terrifying nuclear disaster prediction for 2023 ![]()
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![]() To turn on screen-reader adjustments at any time, users need only to press the Alt+1 keyboard combination. It will also extract texts that are embedded within the image, using an OCR (optical character recognition) technology. Additionally, the background process scans all of the website’s images and provides an accurate and meaningful image-object-recognition-based description as an ALT (alternate text) tagįor images that are not described. For example, we provide accurate form labels ĭescriptions for actionable icons (social media icons, search icons, cart icons, etc.) validation guidance for form inputs element roles such as buttons, menus, modal dialogues (popups),Īnd others. In this process, we provide screen-readers with meaningful data using the ARIA set of attributes. Screen-reader optimization: we run a background process that learns the website’s components from top to bottom, to ensure ongoing compliance even when updating the website. Here’s how our website covers some of the most important screen-reader requirements,Īlongside console screenshots of code examples: As soon as a user with a screen-reader enters your site, they immediately receiveĪ prompt to enter the Screen-Reader Profile so they can browse and operate your site effectively. Screen-readers are able to read, comprehend, and enjoy the website’s functions. Our website implements the ARIA attributes (Accessible Rich Internet Applications) technique, alongside various different behavioral changes, to ensure blind users visiting with You can reach out to the website’s operators by using the following email Screen-reader and keyboard navigation If you’ve found a malfunction or have ideas for improvement, we’ll be happy to hear from you. This application remediates the website’s HTML,Īdapts Its functionality and behavior for screen-readers used by the blind users, and for keyboard functions used by individuals with motor impairments. We utilize an accessibility interface that allows persons with specificĭisabilities to adjust the website’s UI (user interface) and design it to their personal needs.Īdditionally, the website utilizes an AI-based application that runs in the background and optimizes its accessibility level constantly. This website utilizes various technologies that are meant to make it as accessible as possible at all times. To all people: blind people, people with motor impairments, visual impairment, cognitive disabilities, and more. Complying with those guidelines helps us ensure that the website is accessible ![]() These guidelines explain how to make web content accessible to people with a wide array of disabilities. ![]() ![]() To fulfill this, we aim to adhere as strictly as possible to the World Wide Web Consortium’s (W3C) Web Content Accessibility Guidelines 2.1 (WCAG 2.1) at the AA level. We firmly believe that the internet should be available and accessible to anyone, and are committed to providing a website that is accessible to the widest possible audience, ![]() ![]() ![]() Food and Drug Administration (FDA) firstly approved ADC drug, Mylotarg ® (gemtuzumab ozogamicin), for adults with acute myeloid leukemia (AML), which marked the beginning of ADC era of cancer targeted therapy. Moreover, owing to the conjugation to a large hydrophilic antibody, the antigen-independent uptake of cytotoxic payload in those antigen-negative cells is limited, contributing to widening therapeutic index. 18 ADC consists of a tumor targeting mAbs conjugated to a cytotoxic payload through a sophisticatedly designed chemical linker, enabling the ability of precise targeting and potent effectiveness simultaneously. 17 Hence, a novel concept, known as antibody–drug conjugate (ADC), was conceived to bridge the gap between the mAb and cytotoxic drug for the improvement of therapeutic window. The emergency of mAbs has changed the paradigm of cancer therapy through precise targeting tumor surface antigens, however, treatment using mAbs alone is often insufficient, potentially due to less satisfactory lethality against cancer cells compared to chemotherapy. 12 In recent decades, an increasing number of mAbs, such as avastin, trastuzumab, rituximab, and cetuximab, have been received approval worldwide for treatment of various solid tumors and hematological cancers. 10, 11 Specific expression of these antigens provides the possibility of precision tumor targeting via monoclonal antibodies (mAbs), and this field was advanced greatly after the development of hybridoma technology since 1975. One of the plausible ways is to identify some specifically overexpressed antigens to distinguish cancer cells from health cells, such as HER2 (human epidermal growth factor receptor 2) on the breast cancer and CD20 (cluster of differentiate 20) on the B cell lymphoma. ![]() ![]() 9 Theoretically, these compounds should be effective in killing cancer cells, but harmless to normal cells. 8 To address this issue, scientists have been working on the development of novel cancer therapeutics with higher targeting ability.Īs early as the beginning of 20th century, Paul Ehrlich first proposed the concept of “magic bullets” and postulate that some compounds could directly access to some desired targets in cell to cure diseases. 3, 4, 5, 6, 7 Most of these chemotherapy agents, however, show low therapeutic index, where severe side effects are generally attributed to non-specific drug exposure to off-target tissues. 2 These cytotoxic agents include analogs of DNA bases (5-fluorouracil and 8-azaguanine), DNA interacting agents (cisplatin and actinomycin D), antimetabolites (aminopterin and methotrexate), and tubulin inhibitors (paclitaxel and vincristine derivatives), etc. 1 Cytotoxic agents based chemotherapy has been the main approach for the treatment of a wide range of cancers for decades. Moreover, we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations, which provide insights for the research and development of novel cancer therapeutics using ADCs.Ĭancer has become the second greatest global health threat, accounting for approximately 10.0 million deaths from cancer occurred in 2020. Herein, we conducted a review of the history and general mechanism of action of ADCs, and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs. This kind of new anti-cancer drugs, known as “biological missiles”, is leading a new era of targeted cancer therapy. Moreover, over 100 ADC candidates have been investigated in clinical stages at present. Since the first ADC, Mylotarg ® (gemtuzumab ozogamicin), was approved in 2000 by the US Food and Drug Administration (FDA), there have been 14 ADCs received market approval so far worldwide. It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells, which has become one of the hotspots for the research and development of anticancer drugs. Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. ![]() ![]() ![]() Known to Kia fans as the original Kia SUV, the Sportage soldiers on today as an intriguing alternative to best-selling small SUVs like the Toyota RAV4. Overall, the Seltos is a competitive if not outstanding entrant in the subcompact SUV category, offering a bit more space than you'd expect. We have no problem calling it an SUV, even if most Seltos drivers won't be blasting through sand dunes like the Seltos in Kia's ad campaign. Perhaps smarting from questions like ours above about whether the Soul is really an SUV, Kia responded with the Seltos, which pairs compact dimensions with tougher styling and available all-wheel drive. What it doesn't offer is all-wheel drive, but unless you need that feature, the Soul might cover all the bases with its funky styling and versatile hatchback configuration. Is it really an SUV? Reasonable folks could differ, but it's a fact that the Soul offers as much maximum cargo capacity as many subcompact SUVs. The Sorento is both easier to park than the Telluride and easier on the wallet, and if the base engine leaves you underwhelmed, the optional turbocharged engine can launch you to 60 mph in just 6.7 seconds, or 0.8 seconds quicker than a Telluride in our testing. Thanks to a redesign for 2021, however, the current Sorento offers significantly more room in the third row, so the Telluride is no longer the automatic choice for buyers wanting adult-friendly space in all three rows. One size down from the Telluride, the Sorento can be equipped with a third-row seat that has historically been rather cramped. It's quite simply the most desirable mainstream three-row SUV on the market. No wonder dealers have been marking this rig up ever since it came out. Delivering roomy seating for three in a stylish package that works just as well for a night on the town, the Telluride is the rare family SUV that can be everything to everyone. The three-row Telluride has been nothing short of a smash hit. Throw in a sleekly futuristic interior and it's no surprise that the EV6 is one of the hottest electrified models of the year. Want more miles? The rear-drive version maxes out at 310, though power drops to 225 hp. Under the surface, the EV6 boasts superfast charge times and your choice of rear- or all-wheel drive, the latter offering 320 horsepower and an EPA-estimated 274 miles of range. The YOUCANIC full system scanner can read and clear fault codes from all the control units.This genre-bending electric vehicle has the same 114.2-inch wheelbase as the hefty Telluride SUV (see below), yet its slinky shape evokes performance coupes and hot hatches. What scanner do I need to read Kia fault codes?Ī good scanner can read all the systems on your Kia. Open the driver’s door and look under the dashboard. The Kia OBD2 port is above the brake pedal, hidden at the end of the dashboard. For more help, see our guide on diagnosing vehicle problems like a Pro Mechanic. Once you find the OBD-II port on a Kia, use it to diagnose vehicle problems. It has 16 pins, and it is distinguishable by its trapezoidal shape. ![]() Some models require that you remove the rectangular fuse box cover if there is any.Look under the dashboard on the driver’s side.Here are the steps to locate the OBD II port on a Kia. This article will teach you how to access the OBDII port on any Kia. Using the OBD-II port, you can diagnose the Check Engine Light, Airbag, Transmission, ECU, SRS, and ABS. The OBD II port on a Kia (Sedona, Sorento, Rio, Optima, Forte, etc.) plugs in a diagnostic scanner to read codes and troubleshoot problems. ![]() ![]() ![]() Tight and hype, this posse of B-Kats will be rockin’ the hop-hop scene. They’re Skat Kat’s krew (they don’t actually refer to them as a crew at any point, but if they did you know it’d start with a k) and “they’re out of the alleys and into the streets, these koolest of kool Kats. The album is as hilarious in concept as it is depressing to think about the music artists who listed this as their one and only “big project.” Let the party begin!!!!!”Īnd yes, they used five exclamation points to start the party. No, literally, the whole thing is written like this, and it’s three fucking pages long. He’s a rapper droppin’ crazy science, and a dancer whose moves set the pace all over the place.” ![]() The memo goes on to say, “Skat Kat is a street philosopher with an alley Kat point of view. Now, again, MC Skat Kat was a fake character who was written by a writer and voiced by two different singers, so that last part actually makes sense in real life. “Ask him where he’s from and you’ll never get the same answer.” “MC Skat Kat is one buggin’ kitty” is how the press release announcement of The Adventures of MC Skat Kat and the Stray Mob begins. The History of The Adventures of MC Skat Kat and the Stray Mob It was produced by Paula Abdul, had a comically “ this is how the young kids talk nowadays right?” press release attached to it, and it is awful. disbanded, the album The Adventures of MC Skat Kat and the Stray Mob was released on Virgin Records. ![]() The song shot up to #1 on the charts, and because music executives are as as they are they decided they were going to cash in (or should we say kash in) on the popularity of this groovy hip hop kat who raps about staying out and partying by giving him his own album. Our staff has long since drunk away any semblance of creativity, so trust us, making up something this comically stupid is beyond us. For those of you too young to remember the music video’s popularity (or those of you too wired on cocaine to remember those years), it was a duet between Paula Abdul and a cartoon cat named “MC Skat Kat” voiced by “The Wild Pair.”Īs with most things that happened between 19, we have to go out of our way to confirm that, yes, this was a thing that actually happened, and no, we’re not making this up. “Hahaha, the late 80s and early 90s were a MESS.”Įveryone loved the 1989 music video for Opposites Attract when it came out, even though it has aged about as gracefully as Laura Flynn Boyle. ![]() ![]() ![]() To compare transaction fees, you will need to consider how much money you plan to process per month. That being said, QuickBooks Payments, PayPal and Square all offer invoicing capabilities, which simplifies the process of billing customers and getting paid. QuickBooks Payments is best thought of as an extra feature for the broader accounting services QuickBooks has to offer. Live chat, phone service, knowledge base, no blog Live chat, phone service, knowledge base and blog Live chat, knowledge base, blog, no phone support WooCommerce, Magento, Wix, BigCommerce, GoDaddy, and more ![]() There is an option to do a free 30-day trial for the first month, but then you’ll pay the standard price starting the second month.ģ.5% plus fixed fee (15 cents for USD), 1.50% additional percentage-based fee for international transactionsĢ.7% plus fixed fee (15 cents for USD) per transactionĪcuity Scheduling, GoDaddy Websites and Marketing, Wix, WooCommerce, JotForm, and more The more extensive plans allow additional users (25 users for the Advanced plan, compared to three users for the Essential plan) and also include analytics and insights, capability to batch invoices and expenses, project profitability and time tracking as well as on-demand training for the most advanced plan. Keep in mind that there are different payment processing fees for each, with the online version slightly higher. This makes it easier to switch between different team members and devices, such as accepting a payment from your smartphone and managing invoices through your computer. The online version is an application that you can access from any device with an internet connection, and your data is stored in the cloud. For some plans, this price works out to be more affordable in the long term. It comes with three years of support and costs $299.99 per year ($199.99 for the first year). The least expensive desktop version (QuickBooks Desktop Pro Plus 2021), is a one-time purchase that you download on your computer. QuickBooks has both an online version and a desktop version, and there are pros and cons for each. If you’re processing over $15,000 per month, there is a $20 per month fee on the QuickBooks Desktop version, but the fees per transaction go down to 1.5% plus 30 cents.
![]() It lets you to download all YouTube channel videos directly as MP3 audio format in one click. Save.Tube is the best MP3 converter for YouTube channel videos, it works on Chrome, Firefox, Edge, Opera, Safari and supports all operating systems like Windows, Linux, Mac OS X, also you can convert and download channel YouTube videos using your mobile phone running Android or iOS. With Save.Tube you can download entire YouTube channels as MP4 videos in one click! We're the fastest online YouTube video downloader and the only tool that lets you download YouTube videos easily from 1080p to 4K and even 8K! instantly and fast. You can easily download and convert YouTube videos to MP3 format directly for offline playback.Įasily convert YouTube videos to any format like MP4, WebM, and MP3 so you can play your downloaded videos on any platform or device like Windows PC, Mac, Linux, iPhone, iPod and Android mobiles. Save.Tube is the best free YouTube to MP3 converter and downloader tool. Save.Tube fully supports mobile phones running Android and iOS, so you can easily download and save your favorite YouTube videos on your mobile phone without any extra tools. Save.Tube is the best free online YouTube video downloader tool to get your favorite video clips from YouTube, it does not only allows you to choose between many formats & qualities but also allows greater download speeds. ![]() You can download YouTube videos in either 30FPS (frames per second) or 60FPS (frames per second) so your downloaded videos will be more smoothly animated. ![]() Save.Tube allows downloading videos & media files with all qualities like FHD, 1080p, Ultra HD, 2K, 4K, 8K, HDR with fast downloading speeds without any waiting time. You can download and save YouTube videos in many formats like MP4, MP3, WebM. Save.Tube is a free online & simple to use platform to download videos and music files from YouTube, Tiktok, Facebook, Instagram, SoundCloud, Twitch, Vimeo, Twitter, bilibili and more than +1000 media sites. ![]() ![]() ![]() Substance Material Examples Wood Collection For full details, take a look at the documentation available in the Help menu of the application.Get started with Adobe Substance 3D? Find more learning content on Substance 3D Tutorials or Substance Youtube channel. Several new functionalities have been added to the Python API. ![]() Improved error message when opening projects that are too recent.New 16f and 32f EXR texture export setting.Tiling fill layers and effects beyond 128.View individual RGBA components in viewports.Reset Substance graph parameters to default.New action to quickly re-import a 3D model.It is always possible to re-open them via the Help menu. Those window can be easily closed and won’t reappear upon next launches. New Welcome and What’s new window To stay informed about new features added to the application we now introduce a new Welcome and What’s new window when launching the application.Miscellaneous features and improvementsĪ lot of small additional improvements and features have been added in this new version: New actions have been added to the Assets window to make management of resources more convenient. New Favorites and delete/reload in Assets window New environment option to light up underneath 3D modelsĪ new setting inside Display Settings allows to align the environment map to the camera making it possible to adjust the lighting angle and light up parts below the 3D model. An SBSAR is a container that can be opened in many applications with Substance integration, which can make it faster and easy to ‘plug-and-play’ custom textures. Substance archive (SBSAR) file format is now available when exporting textures. Before it was necessary to create complex layer configurations (like passthrough layers or anchor points) to achieve the same result. New effects on foldersįolder content (the color part of a layer) can now receive effects of any kind. New blending mode and opacity on filter and color selection effectsįilter and color selection effects now have the possibility to use blending modes and opacity controls. Several shortcuts and actions have been added to make it quick and easy to copy and apply blending modes and the opacity across multiple channels in the Layer Stack. Major features New options to apply blending modes and opacity Substance 3D Painter 8.2 focuses on a lot of quality-of-life improvements with dedicated features in several areas of the application. Apple Silicon native support (M1 / M2) for Steam version.Resolve scaling issues for high-DPI screens.Two buttons widget for exposed boolean parameters.These two panels are also accessible from the Help menu. Then, the What’s new panel – displayed the first time you run a new version of Designer – quickly presents the main features introduced in this version. We have introduced two new panels to help you to get started with Designer:įirst, the Welcome panel – displayed the first time you launch Designer – offers a global overview of the software and its role in the Substance 3D ecosystem. ![]() Other improvements for Substance model graphs This is now possible also for Substance model graphs: just drag & drop your subgraph from the Explorer to your main graph to use it as an instance node. If you are used to creating graphs, you want to be able to make subgraphs (or graph instances) in order to reuse your work, make graphs less cluttered and be more efficient. Major features Support of Graph Instances in Substance model graphs This version also introduces two new panels ( Welcome and What’s New) to improve user onboarding, and some other minor features or bug fixes described below. Substance 3D Designer 12.3 brings Substance model graphs to a new level with the support of subgraphs (or graph instances), plus the ‘ Visible if‘ control for exposed parameters and some new nodes dedicated to curves edition. What’s new in Substance 3D Designer v12.3 The updates to Substance 3D Designer and Painter add to that with new several features and improvements.ĭesigner and Painter are part of the Substance ecosystem of apps and content that empower you to design 3D. The smart creative apps and high-end content in Adobe Substance 3D give you everything you need to make great art. ![]() ![]() They also double as a backup tool allowing you to sync other types of files and perform backups and restores. Their ability to help you sync your notes is just one of their multiple functions. If none of these methods work, you can get the help of iPhone data transfer software like EaseUS MobiMover or FoneDog.
![]() $234,680 - that’s the amount my parents invested in my higher education in the US. The youngest director at the Pentagon is a Latina Start a chapter in your city! Apply here ![]() ![]() □□Don't forget about our Rise Up, Break Through - Latinas of Influence event, in person, at UC Berkeley on Tues. #LatinaProfessionalsīe part of the largest and fastest growing community of rising Latinas. She hope that her story inspires the next generation of students and serves as a reminder that our voices matter and we are ready to lead. This article means a lot to her as it highlights the journey that led her to the Pentagon - a journey that spans multiple continents, her family’s immigrant roots, and her own American dream. My seat at the table is one that I have had to fight for and it could not have been done without a strong community behind me." She says "I understand now that there will be many situations where I will be the youngest, be one of the few women, or be the only person of color in the room. Later she realize that it is all about being adaptable (even to your own title), stepping up to the plate, learning fast, and staying humble.Īs time has gone by, she reflects on that first day and if she could give advice to the younger Latinas, I’d be "there was no reason to doubt your ability to lead a team and thrive in the role". Later that day, she was given an organizational chart, and when she saw: “Director of Strategic Communications, Elsa Alvarado,” she was shocked and in awe. “Your team?” she was 24, had recently finished working on campaign work, and certainly she did not feel ready to lead a team. Her first day at the Pentagon was full of surprises, especially when she heard Helen Conine, HR Director, say: “Your team has been waiting for you!” Department of Defense as the youngest Latina Director. #LatinaSpotlight Congratulations Elsa Alvarado, who on April 19, 2021, joined the U.S. ![]() Synthesia raises $50M to leverage synthetic avatars for corporate training and more > Ryan Peterson / Ben Braverman, co-founders of Ĭoverage from Venture, Forbes, Reuters et cetera below □ > Des Traynor, co-founder of Intercom.io Grateful to welcome Josh Coyne, Vidu Shanmugarajah + a bunch of A+ founders and CEOs to the team! So excited to double down on delivering the best AI video platform for our customers & enabling a future of video production without the need for cameras, studios and actors. This year we've seen the adoption of AI video skyrocket and our amazing customers have generated more than 6 million unique videos. Big milestone for us at Synthesia: We raised a $50m Series B led by Kleiner Perkins w/ follow-on from Google Ventures and some of the world's best founders and CEO's □□ ![]() |